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GIOTRIF® is the first approved irreversible ErbB family blocker6

  • The ErbB family of receptors is composed of 4 members: EGFR (ErbB1), HER2 (ErbB2), ErbB3 and ErbB45
  • ErbB family members dimerise with other ErbB family members to signal5
  • EGFR mutations trigger aberrant ErbB family signalling, a key driver in the growth and spread of EGFR M+ NSCLC5
  • Whereas first-generation TKIs, such as gefitinib, reversibly inhibit EGFR, second-generation GIOTRIF® irreversibly blocks signalling from all ErbB family receptors5,7,8

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