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Watch Sanjay popat discuss the QoL results of the LUX-Lung 3 trial!

GIOTRIF® significantly improved dyspnoea and some pain symptoms compared with pemetrexed/cisplatin1

LUX-Lung 3: Median TTD of symptoms. EORTC QoLQLQ-C30 and QLQ LC-13

  • More patients (≥50%) on GIOTRIF® experienced clinically meaningful improvements in pre-specified tumour symptoms (dyspnoea, pain and cough)1

GIOTRIF® delayed time to worsening of clinically relevant symptoms versus pemetrexed/cisplatin1

Compared with chemotherapy, GIOTRIF® delayed time to deterioration of cough (27 vs 8 months, P=0.006), dyspnoea (10.4 vs 2.9 months, P=0.013) and pain (4.2 vs 3.1 months, P=0.188), respectively2

GIOTRIF® significantly improved QoL versus pemetrexed/cisplatin1

Global health status and functioning. EORTC QoLQLQ-C30 questionnaire scores longitudinal analysis

  • GIOTRIF® had significantly better mean QoL scores over time for global health status/QoL, physical role, and cognitive functioning1

CI=confidence interval; EGFR M+=epidermal growth factor receptor mutation positive; EORTC=European Organisation for Research and Treatment of Cancer; QoL=quality of life; TTD=time to deterioration, the time from randomisation to first appearance of a score ≥10 points lower than the baseline score.

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Learn how Frank Griesinger's patient benefited from switching to afatinib from chemotherapy!


Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials

Yang et al., The Lancet Oncology, Volume 16, Issue 2, February 2015, Pages 141-151

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References

  1. Yang JC et al. J Clin Oncol. 2013;31(27):3342-3350.
  2. Wu YL et al. Poster presented at: ESMO Congress; Madrid, Spain; 26-30 September 2014.
  3. Yang JC et al. Lancet Oncol. 2015;16(2):141-151.
  4. Schuler M et al. J Thorac Oncol. 2016;11(3):380-390.
  1. Sequist LV et al. J Clin Oncol. 2013;31(27):3327-3334.

  2. Wu YL et al. Lancet Oncol. 2014;15(2):213-222.

  3. Yang JC et al. Lancet Oncol. 2015;16(2):141-151.

  4. Park K et al. Lancet Oncol. 2016;17(5):577-589.

  5. Soria JC et al. Lancet Oncol. 2015;16(8):897-907.

  6. Solca F et al. J Pharmacol Exp Ther. 2012;343(2):342-350.

  7. Yang JC et al. J Clin Oncol. 2013;31(27):3342-3350.

  8. Hirsch V et al. Poster #369 presented at: American Society of Clinical Oncology (ASCO) Annual Meeting; Chicago, IL, USA; 3-7 June 2016.

  9. Yang JCH et al. Ann Oncol. 2016;27(11):2103-2110.

  10. Schuler M et al. J Thorac Oncol. 2016;11(3):380-390.

  11. Paz-Arez L et al. Ann Oncol. 2017; doi: 10.1093/annonc/mdw611.

  12. GIOTRIF® (afatinib) Summary of Product Characteristics, 2016.

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