Watch Vera Hirsh on AE management and treatment discontinuation!
PFS (LUX-Lung 7 clinical data)
GIOTRIF® (afatinib) significantly improved PFS versus gefitinib1
- 27% reduction in relative risk of disease progression versus gefitinib (HR=0.73; 95% CI, 0.57–0.95; P=0.017)1
- Patients were twice as likely to be alive and progression-free at 2 years versus gefitinib1
- PFS benefit consistent across subgroups, including EGFR mutation type1
ORR (LUX-Lung 7 clinical data)
GIOTRIF® (afatinib) significantly improved response rates versus gefitinib in patients with both del19 and L858R1
- Improved ORR and disease control rates versus gefitinib (ORR: 70% vs 56%; P=0.0083)1
- Longer duration of response versus gefitinib (10.1 vs 8.4 months, respectively)1
ORR=objective response rate; PFS=progression-free survival; TTF=time to treatment failure.
TTF (LUX-Lung 7 clinical data)
Patients remained on treatment with GIOTRIF® (afatinib) significantly longer than with gefitinib1
- GIOTRIF® (afatinib) significantly extended TTF versus gefitinib1
- TTF chosen to reflect real-world clinical practice and treatment guidelines; ~30% of patients continued on treatment with TKIs beyond radiological progression in the absence of clinical deterioration1
- 27% significant reduction in relative risk of treatment failure versus gefitinib (P=0.0073)1
CI=confidence interval; EGFR=epidermal growth factor receptor; HR=hazard ratio; PFS=progression-free survival.